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Metabolism Diazepam is N-demethylated by CYP3A4 and 2C19 for the Energetic metabolite N-desmethyldiazepam, which is hydroxylated by CYP3A4 on the active metabolite temazepam.For the reason that diazepam has a protracted half-existence, it is important to consider it on an everyday routine. This tends to assistance to make certain that the medicatio